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| Nomenclature |
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Symbol:
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Aiy
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Name:
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nonagouti;
intermediate yellow
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MGI ID: |
MGI:1855933 |
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Gene:
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a
Location:
Chr2:154617138-154876748 bp, + strand
Genetic Position: Chr2,
89.0 cM
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Mutation
origin |
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Strain of Origin:
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C3H/HeJ
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Transposon insertion |
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This allele is the result of a 1 kb intracisternal A particle (IAP) transposon insertion. Genomic Southern hybridization analysis places the insertion just upstream of exon 2. (J:19977) |
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Inheritance: |
Dominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  hm1
Disease Model |
Aiy/Aiy |
C3H/HeJ-Aiy |
pigmentation skin/coat/nails growth/size
| Models with phenotypic similarity to human diseases not associated with human ASIP. |
| Obesity |
| J:30922 |
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| Genotype | Allelic Composition | Genetic Background |
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ht2
Disease Model |
Aiy/A |
C3H/HeJ-Aiy |
pigmentation skin/coat/nails growth/size
| Models with phenotypic similarity to human diseases not associated with human ASIP. |
| Obesity |
| J:30922 |
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Disease
models
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Notes |
The Avy allele arose spontaneously in the C3H/HeJ strain. Heterozygotes (Aiy/a) are sootier than Ay/a and are often indistinguishable from A/a. They do not have the mottling often observed in Avy/a. Homozygotes are viable, as are Avy/Ay and Aiy/Avy (J:13441).
Genbank ID for this mutation: S74469
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| References |
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