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| Nomenclature |
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Symbol:
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Avy
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Name:
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nonagouti;
viable yellow
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MGI ID: |
MGI:1855930 |
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Gene:
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a
Location:
Chr2:154617138-154876748 bp, + strand
Genetic Position: Chr2,
89.0 cM
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Spectrum of coat colors in Avy/a mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C3H/HeJ
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Transposon insertion |
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An intracisternal A particle (IAP) retrotransposon is inserted 100kb upstream of agouti coding sequences causing ectopic, allele-specific imprinting of agouti protein expression. (J:19977, J:21244, J:79708) |
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Inheritance: |
Dominant |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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Notes |
The Avy allele arose spontaneously in the C3H/HeJ strain. Avy resembles Ay except that homozygotes are viable and resemble heterozygotes with lower members of the series. Both homozygotes (Avy/Avy) and heterozygotes (Avy/A and Avy/a) show considerable variation in appearance, ranging from clear yellow, through mottling with dark patches, to a completely agouti-like coat (J:5475). The variation is strongly influenced by the agouti-locus genotype and strain genome of the dam (J:6103). A larger proportion of homozygotes than heterozygotes are clear yellow (J:13080). In combination with the dominant spotting allele KitW-2J, Avy heterozygotes that have the agouti phenotype have much larger white spots than those of yellow or mottled yellow phenotype (J:12035). Homozygotes and heterozygotes tend to become obese, and the degree of obesity is correlated with the amount of yellow in the coat (J:13142), except that Eso prevents synthesis of yellow pigment in Avy/- mice but does not prevent obesity (J:6103). Avy resembles a in causing greater tumor susceptibility and lower graft vs. host reactivity (J:5320) and higher hepatic malic enzyme activity (J:5759). The greater tumor susceptibility as well as several altered immune responses occur in Avy/a mice of mottled phenotype but not in those of agouti phenotype (J:7421).
Genbank ID for this mutation: S74479
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| References |
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Original: |
J:13080
DICKIES MM,
"A new viable yellow mutation in the house mouse."
J Hered 1962 Mar-Apr;53():84-6
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All: |
46 reference(s)
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