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Acsl4 Gene Detail
 Symbol
Name
ID
Acsl4
acyl-CoA synthetase long-chain family member 4
MGI:1354713


Nomenclature History
Synonyms 9430020A05Rik, ACS4, Facl4, Lacs4
Genetic Map
Chromosome X
Syntenic
 
Mapping data( 3)
Sequence Map
ChrX:138752536-138825078 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: human long-chain-fatty-acid-CoA ligase
TreeFam: TF314012
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000018811 VEGA Gene Model | MGI Sequence Detail 72543 C57BL/6J ± Kb
transcript NM_207625 RefSeq | MGI Sequence Detail 5280 C57BL/6
polypeptide Q9QUJ7 UniProt | EBI | MGI Sequence Detail 711 Not Applicable
For the selected sequences
All sequences(44)
Alleles
and
phenotypes
All alleles(11) : Targeted, knock-out(1) Gene trapped(10)
Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.
Polymorphisms SNPs within 2kb(297 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process embryonic process involved in female pregnancy, fatty acid metabolic process...
Component endoplasmic reticulum, integral to membrane...
Function ATP binding, catalytic activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (12)    Tissues (7)
Theiler Stages: 24,28
  Assay Type Assays   Results
      RT-PCR 1   6
      Northern blot 1   6
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(4)
Pathways
fatty acid β-oxidation I
fatty acid β-oxidation II (core pathway)
fatty acid activation
Other database
links
EC 6.2.1.3
Ensembl Gene Model ENSMUSG00000031278
DoTS DT.101365416, DT.101365621, DT.111024386, DT.486629
Consensus CDS Project CCDS30448.1, CCDS41156.1
DFCI TC1579639, TC1589561, TC1597775, TC1634075, TC1747857
NIA Mouse Gene Index U039748
Entrez Gene 50790
VEGA Gene Model OTTMUSG00000018811
International Mouse Knockout Project Status Acsl4
Protein
domains
InterPro ID Description
IPR000873 AMP-dependent synthetase/ligase
IPR020845 AMP-binding, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:60348 Li Z et al., "Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]" Science 2000 Feb 11;287(5455):1046-9
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(14)
Other
accession IDs
MGI:2147955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory