Symbol
Name
ID
|
|
|
Synonyms
|
c-COT, Cot, Cot/Tpl2, Tpl-2, Tpl2
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(22)
|
Alleles
and
phenotypes
|
All alleles(4) :
Targeted, knock-out(3)
Chemically induced(1)
| Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed. |
|
|
Polymorphisms
|
RFLP(1)
SNPs within 2kb(81 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (1 records)
Data Summary:
Assays (1)
Results (31)
Tissues (19)
Theiler Stages: 22,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RNA in situ |
1 |
|
31 |
cDNA source data(22)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(29)
Genomic(6)
cDNA(23)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR017424 |
Mitogen-activated protein kinase kinase kinase 8 |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:1701
Justice MJ et al.,
"A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18."
Genomics 1992 Aug;13(4):1281-8
(Latest)
J:152170
Kaiser F et al.,
"TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells."
J Exp Med 2009 Aug 31;206(9):1863-71
|
All references(28)
|
Other
accession IDs
|
MGD-MRK-15201, MGD-MRK-2095, MGI:88472, MGI:98808
|
Analysis Tools
MGI BioMart
