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Map3k7 Gene Detail
 Symbol
Name
ID
Map3k7
mitogen-activated protein kinase kinase kinase 7
MGI:1346877

Nomenclature History
Synonyms TAK1, Tak1, TGF-beta activated kinase 1, transforming growth factor beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
Genetic Map
Chromosome 4
Syntenic
 
Mapping data( 4)
Sequence Map
Chr4:32051072-32110442 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Protein SuperFamily: mitogen-activated protein kinase kinase kinase 7
TreeFam: TF105116
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000004905 VEGA Gene Model | MGI Sequence Detail 59371 C57BL/6J ± Kb
transcript NM_009316 RefSeq | MGI Sequence Detail 5763 C57BL/6
polypeptide Q62073 UniProt | EBI | MGI Sequence Detail 579 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(55) : Targeted, knock-out(2) Targeted, other(3) Gene trapped(50)
Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Mice with conditional deletion in immune cells show impaired cell development and activation.
Polymorphisms SNPs within 2kb(432 from dbSNP Build 128)   SNPs within 2kb including multiple locations(434)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process angiogenesis, I-kappaB phosphorylation...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Assays (2)    Results (57)    Tissues (49)    Images (18)
Theiler Stages: 14,17,18,19,20,21,22,23
  Assay Type Assays   Results
      RT-PCR 1   11
      Immunohistochemistry 1   46
cDNA source data(113)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(116) Genomic(1) cDNA(113) Primer pair(2) Antibodies(1)
Microarray probesets(4)
Other database
links
EC 2.7.11.25
Ensembl Gene Model ENSMUSG00000028284
DoTS DT.40153384, DT.531819, DT.99606230
Consensus CDS Project CCDS18014.1
UniGene 258589
DFCI TC1577998, TC1591499, TC1670702
NIA Mouse Gene Index U042512
Entrez Gene 26409
VEGA Gene Model OTTMUSG00000004905
International Mouse Knockout Project Status Map3k7
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR015786 Mitogen activated protein kinase kinase kinase-related
IPR017421 Mitogen-activated protein kinase kinase kinase 7
IPR017441 Protein kinase, ATP binding site
Graphical View of Protein Domain Structure
References
(Earliest) J:47270 Yamaguchi K et al., "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction." Science 1995 Dec 22;270(5244):2008-11
(Latest) J:156178 Long M et al., "Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor." Immunity 2009 Dec 18;31(6):921-31
All references(49)
Other
accession IDs 		MGI:1203726, MGI:2135559
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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