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Mapk8 Gene Detail
 Symbol
Name
ID
Mapk8
mitogen-activated protein kinase 8
MGI:1346861


Nomenclature History
Synonyms c-Jun N-terminal kinase, JNK1, Prkm8
Genetic Map
Chromosome 14
cytoband B
 
Mapping data( 3)
Sequence Map
Chr14:34191084-34260344 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF105100
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000018229 VEGA Gene Model | MGI Sequence Detail 69261 C57BL/6J ± Kb
transcript NM_016700 RefSeq | MGI Sequence Detail 5770 C57BL/6
polypeptide Q91Y86 UniProt | EBI | MGI Sequence Detail 384 Not Applicable
For the selected sequences
All sequences(40)
Alleles
and
phenotypes
All alleles(23) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(20)
Phenotype Images (4)  
Polymorphisms SNPs within 2kb(254 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(20)
Process induction of apoptosis in response to chemical stimulus, JUN phosphorylation...
Component cytoplasm, nucleus...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression Literature Summary: (38 records)
Data Summary: Assays (12)    Results (43)    Tissues (12)    Images (13)
Theiler Stages: 20,21,24,26,28
  Assay Type Assays   Results
      Western blot 11   41
      Immunohistochemistry 1   2
cDNA source data(77)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(81) Genomic(1) cDNA(80) Antibodies(9)
Microarray probesets(3)
Other database
links
EC 2.7.11.24
Ensembl Gene Model ENSMUSG00000021936
DoTS DT.533449, DT.97390242, DT.97398944
UniGene 21495
DFCI TC1577892, TC1592768, TC1598120
NIA Mouse Gene Index U035398
Entrez Gene 26419
VEGA Gene Model OTTMUSG00000018229
International Mouse Knockout Project Status Mapk8
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR003527 MAP kinase, conserved site
IPR008271 Serine/threonine-protein kinase, active site
IPR008351 JNK MAP kinase
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:51510 Dong C et al., "Defective T cell differentiation in the absence of Jnk1." Science 1998 Dec 11;282(5396):2092-5
(Latest) J:153050 Bogani D et al., "Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination." PLoS Biol 2009 Sep;7(9):e1000196
All references(167)
Other
accession IDs
MGI:1328367, MGI:2145699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory