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Mapk1 Gene Detail
 Symbol
Name
ID
Mapk1
mitogen-activated protein kinase 1
MGI:1346858

Nomenclature History
Synonyms 9030612K14Rik, Erk2, MAPK2, p42mapk, Prkm1
Genetic Map
Chromosome 16
9.82 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr16:16983475-17047546 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Mapk1 ± 2 cM)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF105097
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020203 VEGA Gene Model | MGI Sequence Detail 64072 C57BL/6J ± Kb
transcript NM_011949 RefSeq | MGI Sequence Detail 5099 C57BL/6
polypeptide P63085 UniProt | EBI | MGI Sequence Detail 358 Not Applicable
For the selected sequences
All sequences(54)
Alleles
and
phenotypes 		All alleles(25) : Targeted, knock-out(5) Targeted, other(4) Gene trapped(16)
Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues.
Polymorphisms RFLP(1) SNPs within 2kb(139 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(35)
Process B cell receptor signaling pathway, cell cycle...
Component cytoplasm, nucleus...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression Literature Summary: (120 records)
Data Summary: Assays (30)    Results (314)    Tissues (178)    Images (44)
Theiler Stages: 2,3,4,5,17,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 20   87
      RT-PCR 3   99
      RNA in situ 2   108
      Immunohistochemistry 5   20
cDNA source data(22)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(32) Genomic(5) cDNA(23) Primer pair(4) Antibodies(20)
Microarray probesets(3)
Other database
links
EC 2.7.11.24
Ensembl Gene Model ENSMUSG00000063358
DoTS DT.101150642, DT.101388611, DT.535488, DT.94313588
DFCI TC1573574, TC1578432, TC1583982, TC1605197
NIA Mouse Gene Index U016859
Entrez Gene 26413
VEGA Gene Model OTTMUSG00000020203
International Mouse Knockout Project Status Mapk1
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR003527 MAP kinase, conserved site
IPR008271 Serine/threonine-protein kinase, active site
IPR008349 ERK1/2 MAP kinase
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:3247 L'Allemain G et al., "Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein." FEBS Lett 1991 Nov 4;292(1-2):191-5
(Latest) J:153980 Matsushita T et al., "Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis." Mol Cell Biol 2009 Nov;29(21):5843-57
All references(264)
Other
accession IDs 		MGD-MRK-33596, MGD-MRK-9584, MGI:105919, MGI:1921796, MGI:2146330, MGI:2146551, MGI:2146700
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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