Symbol
Name
ID
|
|
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Synonyms
|
BETA2, BHF-1, bHLHa3, Neurod
|
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Genetic Map
|
|
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Sequence Map
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Mammalian
homology
|
|
|
Sequences
|
All sequences(21)
|
Alleles
and
phenotypes
|
All alleles(4) :
Targeted, knock-out(1)
Targeted, other(3)
| Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
|
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Polymorphisms
|
RFLP(1)
SNPs within 2kb(20 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (173 records)
Data Summary:
Assays (39)
Results (346)
Tissues (234)
Images (94)
Theiler Stages: 2,3,4,5,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
2 |
|
2 |
| |
RT-PCR |
8 |
|
35 |
| |
RNA in situ |
23 |
|
253 |
| |
Immunohistochemistry |
4 |
|
17 |
| |
Northern blot |
2 |
|
39 |
cDNA source data(42)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(65)
Genomic(1)
cDNA(46)
Primer pair(10)
Other(8)
Antibodies(3)
Microarray probesets(3)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001092 |
Helix-loop-helix DNA-binding domain |
| IPR011598 |
Helix-loop-helix DNA-binding |
| IPR016637 |
Transcription factor, basic helix-loop-helix, NeuroD |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:25296
Lee JE et al.,
"Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein."
Science 1995 May 12;268(5212):836-44
(Latest)
J:153561
Dominguez-Frutos E et al.,
"Tissue-specific requirements for FGF8 during early inner ear development."
Mech Dev 2009 Oct;126(10):873-81
|
All references(204)
|
Other
accession IDs
|
MGD-MRK-26011, MGI:104577
|
