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Pak3 Gene Detail
 Symbol
Name
ID
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
MGI:1339656


Nomenclature History
Synonyms PAK-3
Genetic Map
Chromosome X
Syntenic
 
Mapping data( 3)
Sequence Map
ChrX:139953134-140232335 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF105351
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000018957 VEGA Gene Model | MGI Sequence Detail 279202 C57BL/6J ± Kb
transcript NM_008778 RefSeq | MGI Sequence Detail 2172 C3H/He
polypeptide Q61036 UniProt | EBI | MGI Sequence Detail 559 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Gene trapped(1)
Polymorphisms RFLP(1) SNPs within 2kb(892 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process multicellular organismal development, protein amino acid phosphorylation...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Assays (4)    Results (39)    Tissues (33)    Images (2)
Theiler Stages: 21,22,24,26,28
  Assay Type Assays   Results
      RNA in situ 3   21
      Northern blot 1   18
cDNA source data(24)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(27)
Microarray probesets(1)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000031284
DoTS DT.60118025, DT.91327589, DT.94189195
Consensus CDS Project CCDS30454.1
UniGene 40035
PDB 1EES
DFCI TC1584463, TC1584764
Entrez Gene 18481
VEGA Gene Model OTTMUSG00000018957
International Mouse Knockout Project Status Pak3
Protein
domains
InterPro ID Description
IPR000095 PAK-box/P21-Rho-binding
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR015750 Serine/threonine-protein kinase, Pak-related
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:29051 Bagrodia S et al., "Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]" J Biol Chem 1995 Sep 29;270(39):22731-7
(Latest) J:149737 Sansom SN et al., "The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis." PLoS Genet 2009 Jun;5(6):e1000511
All references(21)
Other
accession IDs
MGD-MRK-33717, MGI:106033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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