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Acox1 Gene Detail
 Symbol
Name
ID
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
MGI:1330812

Nomenclature History
Synonyms Acyl-CoA oxidase, AOX, D130055E20Rik
Genetic Map
Chromosome 11
Syntenic
 
Mapping data( 3)
Sequence Map
Chr11:116033202-116060359 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: acyl-CoA oxidase
TreeFam: TF300672
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003754 VEGA Gene Model | MGI Sequence Detail 27158 C57BL/6J ± Kb
transcript NM_015729 RefSeq | MGI Sequence Detail 4065 C57BL/6
polypeptide Q9R0H0 UniProt | EBI | MGI Sequence Detail 661 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Gene trapped(2)
Mice homozygous for a targeted mutation that inactivates the gene show growth retardation, infertility, excess very long chain fatty acids in the blood, and progressive liver disease, including hepatomegaly, and hepatic adenomas and carcinomas.
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (1)   Phenotype Images (3)  
Polymorphisms SNPs within 2kb(112 from dbSNP Build 128)   SNPs within 2kb including multiple locations(114)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process...
Component cytoplasm, mitochondrion...
Function acyl-CoA dehydrogenase activity, acyl-CoA oxidase activity...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Assays (15)    Results (190)    Tissues (118)    Images (19)
Theiler Stages: 15,19,20,22,23,24,26,28
  Assay Type Assays   Results
      Western blot 4   23
      RT-PCR 3   15
      RNA in situ 1   93
      Northern blot 7   59
cDNA source data(260)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(272) Genomic(2) cDNA(266) Primer pair(4) Antibodies(3)
Microarray probesets(3)
Pathways
fatty acid β-oxidation II (core pathway)
Other database
links
EC 1.3.3.6
Ensembl Gene Model ENSMUSG00000020777
DoTS DT.101266055, DT.101374584, DT.94303614, DT.94377781
Consensus CDS Project CCDS25660.1
UniGene 356689
DFCI TC1572314, TC1583948
NIA Mouse Gene Index U033646
Entrez Gene 11430
VEGA Gene Model OTTMUSG00000003754
International Mouse Knockout Project Status Acox1
Protein
domains
InterPro ID Description
IPR002655 Acyl-CoA oxidase, C-terminal
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase
IPR012258 Acyl-CoA oxidase
IPR013764 Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:35794 Fan CY et al., "Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene." J Biol Chem 1996 Oct 4;271(40):24698-710
(Latest) J:154032 Guo Y et al., "Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles." PLoS One 2009;4(10):e7641
All references(32)
Other
accession IDs 		MGI:2141377, MGI:2441945
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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