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Ppp2cb Gene Detail
 Symbol
Name
ID
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
MGI:1321161

Nomenclature History
Synonyms D8Ertd766e, PP2Ac
Genetic Map
Chromosome 8
20.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr8:34710097-34730266 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppp2cb ± 2 cM)
Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
TreeFam: TF105551
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000009630 Ensembl Gene Model | MGI Sequence Detail 20170 C57BL/6J ± Kb
transcript NM_017374 RefSeq | MGI Sequence Detail 1836 C57BL/6
polypeptide P62715 UniProt | EBI | MGI Sequence Detail 309 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes 		All alleles(15) : Gene trapped(15)
Polymorphisms SNPs within 2kb(131 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process negative regulation of apoptosis, proteasomal ubiquitin-dependent protein catabolic process...
Component chromosome, centromeric region, cytoplasm...
Function hydrolase activity, iron ion binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (12)    Tissues (4)
Theiler Stages: 28
  Assay Type Assays   Results
      Western blot 1   4
      RT-PCR 2   8
cDNA source data(10)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(14) cDNA(11) Primer pair(3) Antibodies(3)
Microarray probesets(3)
Other database
links
EC 3.1.3.16
Ensembl Gene Model ENSMUSG00000009630
Consensus CDS Project CCDS22233.1
NIA Mouse Gene Index U141747
Entrez Gene 19053
International Mouse Knockout Project Status Ppp2cb
Protein
domains
InterPro ID Description
IPR004843 Metallophosphoesterase
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Graphical View of Protein Domain Structure
References
(Earliest) J:37188 Kato S et al., "Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules." FEBS Lett 1996 Nov 4;396(2-3):293-7
(Latest) J:156367 Henmi T et al., "A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2." Biochem J 2009 Oct 1;423(1):71-8
All references(19)
Other
accession IDs 		MGI:1289237, MGI:2142462
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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