Symbol
Name
ID
|
Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
MGI:1321159
|
Nomenclature History
|
|
|
Synonyms
|
PP2A
|
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Genetic Map
|
|
Chromosome 11
|
Syntenic
|
|
|
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Mapping data(
3)
|
|
|
|
Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(27)
|
Alleles
and
phenotypes
|
All alleles(17) :
Targeted, knock-out(2)
Gene trapped(15)
| Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed. |
|
|
Polymorphisms
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SNPs within 2kb(32 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
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|
Expression
|
Literature Summary: (7 records)
Data Summary:
Assays (5)
Results (28)
Tissues (12)
Images (2)
Theiler Stages: 17,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
3 |
|
20 |
| |
RT-PCR |
2 |
|
8 |
cDNA source data(301)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(306)
Genomic(3)
cDNA(301)
Primer pair(2)
Antibodies(3)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR004843 |
Metallophosphoesterase |
| IPR006186 |
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:50519
Gotz J et al.,
"Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha."
Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12370-5
(Latest)
J:141318
Bruchert N et al.,
"Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality."
Am J Physiol Heart Circ Physiol 2008 Oct;295(4):H1539-46
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All references(30)
|
Other
accession IDs
|
MGI:2144711
|
Analysis Tools
MGI BioMart