Symbol
Name
ID
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(24)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, knock-out(1)
Targeted, other(2)
Spontaneous(1)
| Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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RFLP(1)
SNPs within 2kb(305 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (2 records)
Data Summary:
Assays (1)
Results (2)
Tissues (2)
Theiler Stages: 21,25
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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2 |
cDNA source data(38)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(44)
Genomic(3)
cDNA(40)
Primer pair(1)
Microarray probesets(3)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000651 |
Ras-like guanine nucleotide exchange factor, N-terminal |
| IPR001895 |
Guanine-nucleotide dissociation stimulator CDC25 |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR008937 |
Ras guanine nucleotide exchange factor |
| IPR011992 |
EF-hand-like domain |
| IPR018247 |
EF-Hand 1, calcium-binding site |
| IPR018249 |
EF-HAND 2 |
| IPR020454 |
Diacylglycerol/phorbol-ester binding |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:46742
Bottorff D et al.,
"RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions."
Mamm Genome 1999 Apr;10(4):358-61
(Latest)
J:147172
Tazmini G et al.,
"Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain."
Biochim Biophys Acta 2009 Mar;1793(3):447-61
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All references(22)
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Analysis Tools
MGI BioMart
