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Fzd9 Gene Detail
 Symbol
Name
ID
Fzd9
frizzled homolog 9 (Drosophila)
MGI:1313278

Nomenclature History
Synonyms frizzled 9, mfz9
Genetic Map
Chromosome 5
75.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 10)

Sequence Map
Chr5:135724808-135727100 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd9 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021311 VEGA Gene Model | MGI Sequence Detail 2293 C57BL/6J ± Kb
transcript NM_010246 RefSeq | MGI Sequence Detail 2110 C57BL/6
polypeptide Q9R216 UniProt | EBI | MGI Sequence Detail 592 Not Applicable
For the selected sequences
All sequences(15)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(3)
Mice homozygous for one allele exhibit immune system abnormalities while another null allele causes neurological abnormalities. A third null mutation results in growth retardation and abnormalities in bone mineralization.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(22 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway...
Component filopodium membrane, integral to membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: FuncBase
Expression Literature Summary: (26 records)
Data Summary: Assays (9)    Results (136)    Tissues (81)    Images (14)
Theiler Stages: 1,2,3,4,5,11,15,17,19,20,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 3   21
      RNA in situ 3   95
      Northern blot 3   20
cDNA source data(8)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(23) Genomic(4) cDNA(12) Primer pair(7)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000049551
DoTS DT.40169831
UniGene 6256
DFCI TC1587026
NIA Mouse Gene Index U026816
Entrez Gene 14371
VEGA Gene Model OTTMUSG00000021311
International Mouse Knockout Project Status Fzd9
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:49924 Wang YK et al., "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome." Genomics 1999 Apr 15;57(2):235-48
(Latest) J:155074 Agalliu D et al., "Motor neurons with axial muscle projections specified by Wnt4/5 signaling." Neuron 2009 Mar 12;61(5):708-20
All references(39)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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