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Nck2 Gene Detail
 Symbol
Name
ID
Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
MGI:1306821

Nomenclature History
Synonyms 4833426I10Rik, Grb4, NCKbeta
Genetic Map
Chromosome 1
cytoband C1
 
Mapping data( 3)
Sequence Map
Chr1:43502596-43627360 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: adapter protein NCK
TreeFam: TF351631
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021065 VEGA Gene Model | MGI Sequence Detail 124765 C57BL/6J ± Kb
transcript NM_010879 RefSeq | MGI Sequence Detail 2789 C57BL/6
polypeptide NP_035009 RefSeq | MGI Sequence Detail 380 C57BL/6
For the selected sequences
All sequences(24)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(1) Targeted, other(3) Gene trapped(2)
Mice homozygous for disruption of this gene display no abnormal phenotype.
Polymorphisms SNPs within 2kb(897 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process actin filament organization, cell migration...
Component vesicle membrane
Function kinase activity
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (4)    Results (91)    Tissues (40)    Images (1)
Theiler Stages: 11,13,17,28
  Assay Type Assays   Results
      Western blot 2   16
      In situ reporter (knock in) 1   67
      Northern blot 1   8
cDNA source data(7)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(8) cDNA(7) Primer pair(1) Antibodies(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000066877, ENSMUSG00000073773
DoTS DT.87072395, DT.97391458, DT.97391459
Consensus CDS Project CCDS14924.1
DFCI TC1578509, TC1587904
NIA Mouse Gene Index U000226, U163976
Entrez Gene 17974
VEGA Gene Model OTTMUSG00000021065
International Mouse Knockout Project Status Nck2
Protein
domains
InterPro ID Description
IPR000980 SH2 motif
IPR001452 Src homology-3 domain
IPR017304 Cytoplasmic, NCK
IPR020473 Src homology-3, region
References
(Earliest) J:39581 Margolis B et al., "High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains." Proc Natl Acad Sci U S A 1992 Oct 1;89(19):8894-8
(Latest) J:152508 Guan S et al., "Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration." J Invest Dermatol 2009 Aug;129(8):1909-20
All references(18)
Other
accession IDs 		MGI:1921842
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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