Symbol
Name
ID
|
|
|
Synonyms
|
6230400I06Rik, Apaf1l
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(31)
|
Alleles
and
phenotypes
|
All alleles(12) :
Targeted, knock-out(2)
Targeted, other(3)
Gene trapped(6)
Spontaneous(1)
| Homozygotes for targeted null mutations have defects in apoptosis resulting in brain overgrowth, craniofacial defects, interdigit webbing and altered lens and retina. Most mutants die by embryonic day 16.5 or perinatally, and male survivors are sterile. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
|
|
Polymorphisms
|
SNPs within 2kb(302 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (1)
Results (24)
Tissues (6)
Theiler Stages: 26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
24 |
cDNA source data(96)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(104)
Genomic(2)
cDNA(101)
Primer pair(1)
Antibodies(1)
Microarray probesets(3)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:40076
Chowdhury K et al.,
"Evidence for the stochastic integration of gene trap vectors into the mouse germline."
Nucleic Acids Res 1997 Apr 15;25(8):1531-6
(Latest)
J:148528
Massa V et al.,
"Apoptosis is not required for mammalian neural tube closure."
Proc Natl Acad Sci U S A 2009 May 19;106(20):8233-8
|
All references(73)
|
Other
accession IDs
|
MGI:1096874, MGI:1277987, MGI:1923379
|
