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Lrp5 Gene Detail
 Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315

Nomenclature History
Synonyms LR3, LRP7
Genetic Map
Chromosome 19
cytoband B
 
Mapping data( 4)
Sequence Map
Chr19:3584869-3686554 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Protein SuperFamily: low density lipoprotein receptor-related protein, 5/6 types
TreeFam: TF315253
Sequences
Representative Sequences Length Strain/Species Flank
genomic 16973 NCBI Gene Model | MGI Sequence Detail 101686 C57BL/6J ± Kb
transcript NM_008513 RefSeq | MGI Sequence Detail 5172 C57BL/6
polypeptide Q91VN0 UniProt | EBI | MGI Sequence Detail 1614 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes 		All alleles(15) : Targeted, knock-out(5) Targeted, other(4) Gene trapped(5) Chemically induced(1)
Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (2)   Phenotype Images (5)  
Polymorphisms SNPs within 2kb(419 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process anterior/posterior pattern formation, cell migration involved in gastrulation...
Component integral to membrane, membrane...
Function receptor activity
External Resources: FuncBase
Expression Literature Summary: (20 records)
Data Summary: Assays (9)    Results (212)    Tissues (149)    Images (27)
Theiler Stages: 1,2,3,4,5,10,18,19,20,22,23,25,28
  Assay Type Assays   Results
      RT-PCR 4   56
      RNA in situ 2   139
      Immunohistochemistry 1   5
      Northern blot 2   12
cDNA source data(81)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(88) Genomic(1) cDNA(81) Primer pair(5) Other(1) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024913
DoTS DT.101238699, DT.101734904, DT.110864077, DT.481503, DT.91429993, DT.97369430
Consensus CDS Project CCDS37881.1
UniGene 274581
DFCI TC1577532, TC1617568, TC1677577, TC1724610, TC1771917
NIA Mouse Gene Index U019112
Entrez Gene 16973
International Mouse Knockout Project Status Lrp5
Protein
domains
InterPro ID Description
IPR000033 Low-density lipoprotein receptor, class B (YWTD) repeat
IPR002172 Low density lipoprotein-receptor, class A (cysteine-rich) repeat
IPR006210 EGF-like
IPR011042 Six-bladed beta-propeller, TolB-like
IPR017049 Low density lipoprotein receptor-related protein, 5/6
Graphical View of Protein Domain Structure
References
(Earliest) J:49544 Hey PJ et al., "Cloning of a novel member of the low-density lipoprotein receptor family." Gene 1998 Aug 17;216(1):103-11
(Latest) J:154863 Junge HJ et al., "TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling." Cell 2009 Oct 16;139(2):299-311
All references(46)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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