Symbol
Name
ID
|
|
|
Synonyms
|
LR3, LRP7
|
|
Genetic Map
|
|
Chromosome 19
|
cytoband B
|
|
|
|
Mapping data(
4)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(32)
|
Alleles
and
phenotypes
|
All alleles(15) :
Targeted, knock-out(5)
Targeted, other(4)
Gene trapped(5)
Chemically induced(1)
| Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
Phenotype Images (5)
|
|
Polymorphisms
|
SNPs within 2kb(419 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (19 records)
Data Summary:
Assays (9)
Results (212)
Tissues (149)
Images (27)
Theiler Stages: 1,2,3,4,5,10,18,19,20,22,23,25,28
| |
Assay Type |
Assays |
|
Results |
| |
Northern blot |
2 |
|
12 |
| |
RT-PCR |
4 |
|
56 |
| |
RNA in situ |
2 |
|
139 |
| |
Immunohistochemistry |
1 |
|
5 |
cDNA source data(81)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(88)
Genomic(1)
cDNA(81)
Primer pair(5)
Other(1)
Antibodies(1)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000033 |
Low-density lipoprotein receptor, class B (YWTD) repeat |
| IPR002172 |
Low density lipoprotein-receptor, class A (cysteine-rich) repeat |
| IPR006209 |
EGF |
| IPR006210 |
EGF-like |
| IPR011042 |
Six-bladed beta-propeller, TolB-like |
| IPR013032 |
EGF-like region, conserved site |
| IPR017049 |
Low density lipoprotein receptor-related protein, 5/6 |
| IPR018097 |
EGF-like calcium-binding, conserved site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:49544
Hey PJ et al.,
"Cloning of a novel member of the low-density lipoprotein receptor family."
Gene 1998 Aug 17;216(1):103-11
(Latest)
J:152469
Badders NM et al.,
"The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage."
PLoS One 2009;4(8):e6594
|
All references(43)
|
