About   Help   FAQ
Tour our new Quick Search
Gck Gene Detail
 Symbol
Name
ID
Gck
glucokinase
MGI:1270854

Nomenclature History
Synonyms Gk, hexokinase 4, HK4, MODY2
Genetic Map
Chromosome 11
1.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr11:5800823-5850084 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gck ± 2 cM)
Protein SuperFamily: hexokinase
TreeFam: TF314238
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000006327 VEGA Gene Model | MGI Sequence Detail 49262 C57BL/6J ± Kb
transcript NM_010292 RefSeq | MGI Sequence Detail 2245 C57BL/6
polypeptide P52792 UniProt | EBI | MGI Sequence Detail 465 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes 		All alleles(27) : Targeted, knock-out(4) Targeted, other(5) Gene trapped(5) Chemically induced(13)
Associated Human Diseases (3)   Alleles Annotated to Human Diseases (20)  
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(72 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process carbohydrate metabolic process, carbohydrate phosphorylation...
Component mitochondrion, soluble fraction...
Function ATP binding, glucokinase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (14 records)
Data Summary: Assays (8)    Results (223)    Tissues (145)    Images (22)
Theiler Stages: 15,22,23,24,28
  Assay Type Assays   Results
      Western blot 1   2
      RT-PCR 4   96
      RNA in situ 3   125
cDNA source data(17)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(45) Genomic(21) cDNA(18) Primer pair(5) Other(1) Antibodies(1)
Microarray probesets(3)
Pathways
glycolysis III
glucose and glucose-1-phosphate degradation
glycogen degradation I
GDP-glucose biosynthesis
trehalose degradation II (trehalase)
Other database
links
EC 2.7.1.2
Ensembl Gene Model ENSMUSG00000041798
DoTS DT.489489, DT.94187311
Consensus CDS Project CCDS24409.1
UniGene 220358
DFCI TC1585582, TC1641456
NIA Mouse Gene Index U032478
Entrez Gene 103988
VEGA Gene Model OTTMUSG00000006327
International Mouse Knockout Project Status Gck
Protein
domains
InterPro ID Description
IPR001312 Hexokinase
IPR019807 Hexokinase, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:5824 Coleman DL, "Genetic control of glucokinase activity in mice." Biochem Genet 1977 Apr;15(3-4):297-305
(Latest) J:139177 Hoffman BG et al., "Identification of transcripts with enriched expression in the developing and adult pancreas." Genome Biol 2008;9(6):R99
All references(56)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory