Symbol
Name
ID
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Synonyms
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Tcf3
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(21)
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Alleles
and
phenotypes
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All alleles(106) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(104)
| Homozygous mice display embryonic lethality and partial or complete anterior-posterior axis structure duplications including the notochord, primitive streak, and neural-folds. Anterior neural structures are absent and abnormalities are seen in the caudal portions of the brain, heart and foregut. |
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Polymorphisms
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SNPs within 2kb(827 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (28 records)
Data Summary:
Assays (8)
Results (159)
Tissues (155)
Images (24)
Theiler Stages: 2,3,4,5,17,18,19,20,21,22,24,28
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Assay Type |
Assays |
|
Results |
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RT-PCR |
2 |
|
18 |
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RNA in situ |
6 |
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141 |
cDNA source data(45)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(48)
cDNA(45)
Primer pair(3)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000910 |
High mobility group, HMG1/HMG2 |
| IPR009071 |
High mobility group, superfamily |
| IPR013558 |
CTNNB1 binding, N-teminal |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:45934
Korinek V et al.,
"Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse."
Mol Cell Biol 1998 Mar;18(3):1248-56
(Latest)
J:152838
Fu H et al.,
"A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development."
J Neurosci 2009 Sep 9;29(36):11399-408
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All references(38)
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