Symbol
Name
ID
|
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Genetic Map
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Chromosome 11
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Syntenic
|
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Mapping data(
2)
|
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(27)
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Alleles
and
phenotypes
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All alleles(69) :
Targeted, other(2)
Gene trapped(67)
| Homozygotes for a targeted null mutation die either during late gestation or around 4-6 weeks, depending on background. Long survivors exhibit growth retardation, neurological abnormalities, and aberrant differentiation of bone marrow stromal cells. |
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Polymorphisms
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SNPs within 2kb(296 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (4)
Results (28)
Tissues (21)
Images (23)
Theiler Stages: 1,2,15,17,20,22,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RNA in situ |
1 |
|
12 |
| |
Immunohistochemistry |
1 |
|
4 |
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Northern blot |
2 |
|
12 |
cDNA source data(57)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(60)
Genomic(2)
cDNA(58)
Antibodies(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR003527 |
MAP kinase, conserved site |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:45651
Brott BK et al.,
"Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus."
Proc Natl Acad Sci U S A 1998 Feb 3;95(3):963-8
(Latest)
J:122362
Harwood BN et al.,
"Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos."
Dev Dyn 2008;237(4):1099-1111
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All references(17)
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Other
accession IDs
|
MGI:2144078
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Analysis Tools
MGI BioMart