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Nfkbie Gene Detail
 Symbol
Name
ID
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
MGI:1194908


Nomenclature History
Genetic Map
Chromosome 17
cytoband C
 
Mapping data( 2)
Sequence Map
Chr17:45692665-45700118 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: NF-kappaB inhibitor
TreeFam: TF320166
Sequences
Representative Sequences Length Strain/Species Flank
genomic 18037 NCBI Gene Model | MGI Sequence Detail 7454 C57BL/6J ± Kb
transcript NM_008690 RefSeq | MGI Sequence Detail 2422 C57BL/6
polypeptide O54910 UniProt | EBI | MGI Sequence Detail 364 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes
All alleles(3) : Targeted, other(2) Gene trapped(1)
Mice homozygous for disruptions of this gene display an essentially normal phenotype.
Polymorphisms SNPs within 2kb(33 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component cytoplasm
Function protein binding, transcription repressor activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (3)    Results (42)    Tissues (34)    Images (4)
Theiler Stages: 17,18,21,26,28
  Assay Type Assays   Results
      RNA in situ 2   33
      Western blot 1   9
cDNA source data(24)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(25) cDNA(25) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000023947
DoTS DT.101362755, DT.531251
Consensus CDS Project CCDS28811.1
UniGene 57043
DFCI TC1579267, TC1593718
NIA Mouse Gene Index U018025
Entrez Gene 18037
International Mouse Knockout Project Status Nfkbie
Protein
domains
InterPro ID Description
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
Graphical View of Protein Domain Structure
References
(Earliest) J:45073 Simeonidis S et al., "Cloning and functional characterization of mouse IkappaBepsilon." Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14372-7
(Latest) J:136288 Molotski N et al., "Teratogen-induced distortions in the classical NF-kappaB activation pathway: correlation with the ability of embryos to survive teratogenic stress." Toxicol Appl Pharmacol 2008 Jun 1;229(2):197-205
All references(15)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory