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Irs3 Gene Detail
 Symbol
Name
ID
Irs3
insulin receptor substrate 3
MGI:1194882


Nomenclature History
Genetic Map
Chromosome 5
cytoband G2
 
Mapping data( 3)
Sequence Map
Chr5:138084260-138086942 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
cattle; rat    (Mammalian Orthology)
TreeFam: TF325994
Sequences
Representative Sequences Length Strain/Species Flank
genomic 16369 NCBI Gene Model | MGI Sequence Detail 2683 C57BL/6J ± Kb
transcript NM_010571 RefSeq | MGI Sequence Detail 2337 C57BL/6
polypeptide NP_034701 RefSeq | MGI Sequence Detail 495 C57BL/6
For the selected sequences
All sequences(18)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Mice homozygous for a targeted mutation are viable, fertile and display no detectable abnormalities in growth or glucose homeostasis.
Polymorphisms RFLP(1) SNPs within 2kb(11 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(1)
Function receptor activity
External Resources: MouseFunc
Expression Literature Summary: (1 records)
Data Summary: Assays (2)    Results (12)    Tissues (12)
Theiler Stages: 10,18,23,25,28
  Assay Type Assays   Results
      Northern blot 2   12
cDNA source data(16)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(16)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000047182
DoTS DT.91560573, DT.94229843
UniGene 24486
DFCI TC1583917, TC1592438
NIA Mouse Gene Index U026852
Entrez Gene 16369
International Mouse Knockout Project Status Irs3
Protein
domains
InterPro ID Description
IPR001849 Pleckstrin homology
IPR002404 Insulin receptor substrate-1, PTB
IPR011993 Pleckstrin homology-type
References
(Earliest) J:43854 Sciacchitano S et al., "Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene." Endocrinology 1997 Nov;138(11):4931-40
(Latest) J:136031 Lee S et al., "Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling." Endocrinology 2008 May;149(5):2451-8
All references(12)
Other
accession IDs
MGI:2140734

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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