About   Help   FAQ
Car4 Gene Detail
 Symbol
Name
ID
Car4
carbonic anhydrase 4
MGI:1096574


Nomenclature History
Synonyms CA IV
Genetic Map
Chromosome 11
Syntenic
 
Mapping data( 1)
Sequence Map
Chr11:84771288-84779546 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Protein SuperFamily: carbonate dehydratase
TreeFam: TF316425
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000001034 VEGA Gene Model | MGI Sequence Detail 8259 C57BL/6J ± Kb
transcript NM_007607 RefSeq | MGI Sequence Detail 1316 C57BL/6
polypeptide Q64444 UniProt | EBI | MGI Sequence Detail 305 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes
All alleles(10) : Targeted, knock-out(1) Gene trapped(9)
Polymorphisms SNPs within 2kb(41 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(12)
Process one-carbon metabolic process
Component anchored to membrane, membrane...
Function carbonate dehydratase activity, lyase activity...
External Resources: MouseFunc
Expression Literature Summary: (5 records)
Data Summary: Assays (4)    Results (98)    Tissues (96)    Images (5)
Theiler Stages: 15,18,22
  Assay Type Assays   Results
      RT-PCR 1   2
      RNA in situ 3   96
cDNA source data(76)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(86) Genomic(7) cDNA(76) Primer pair(3)
Microarray probesets(3)
Other database
links
EC 4.2.1.1
Ensembl Gene Model ENSMUSG00000000805
DoTS DT.533723
UniGene 1641
PDB 2ZNC, 3ZNC
DFCI TC1576825
NIA Mouse Gene Index U013114
Entrez Gene 12351
VEGA Gene Model OTTMUSG00000001034
International Mouse Knockout Project Status Car4
Protein
domains
InterPro ID Description
IPR001148 Carbonic anhydrase, alpha-class, catalytic domain
IPR018338 Carbonic anhydrase, alpha-class, conserved site
IPR018343 Carbonic anhydrase, CA-IV
Graphical View of Protein Domain Structure
References
(Earliest) J:18790 Brion LP et al., "Up-regulation of carbonic anhydrase isozyme IV in CNS myelin of mice genetically deficient in carbonic anhydrase II." J Neurochem 1994 Jul;63(1):360-6
(Latest) J:153753 Chandrashekar J et al., "The taste of carbonation." Science 2009 Oct 16;326(5951):443-5
All references(20)
Other
accession IDs
MGI:2144530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/20/2009
MGI_4.31
Web browser compatibility
The Jackson Laboratory