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Arntl Gene Detail
 Symbol
Name
ID
Arntl
aryl hydrocarbon receptor nuclear translocator-like
MGI:1096381


Nomenclature History
Synonyms Arnt3, bHLHe5, Bmal1, MOP3
Genetic Map
Chromosome 7
52.0 cM, cytoband F2-F3
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr7:120350979-120457636 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Arntl ± 2 cM)
TreeFam: TF319983
Sequences
Representative Sequences Length Strain/Species Flank
genomic 11865 NCBI Gene Model | MGI Sequence Detail 106658 C57BL/6J ± Kb
transcript NM_007489 RefSeq | MGI Sequence Detail 2904 C57BL/6
polypeptide Q9WTL8 UniProt | EBI | MGI Sequence Detail 632 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes
All alleles(80) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(77)
Homozygous mutation of this gene results in abnormal light/dark cycle activity and decreases overall activity levels.
Polymorphisms RFLP(1) SNPs within 2kb(541 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(25)
Process circadian rhythm, positive regulation of transcription from RNA polymerase II promoter...
Component nucleus, transcription factor complex...
Function DNA binding, protein binding...
External Resources: MouseFunc
Expression Literature Summary: (8 records)
Data Summary: Assays (7)    Results (88)    Tissues (59)    Images (4)
Theiler Stages: 1,2,3,4,5,17,21,28
  Assay Type Assays   Results
      RT-PCR 3   36
      RNA in situ 3   44
      Northern blot 1   8
cDNA source data(53)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(55) cDNA(54) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000055116
DoTS DT.101372098, DT.103561983, DT.111014059, DT.40171997, DT.489401, DT.97405406
UniGene 440371
DFCI TC1577063, TC1595418, TC1611296, TC1637310, TC1698649
NIA Mouse Gene Index U008650, U232917
Entrez Gene 11865
International Mouse Knockout Project Status Arntl
Protein
domains
InterPro ID Description
IPR000014 PAS
IPR001067 Nuclear translocator
IPR001092 Helix-loop-helix DNA-binding domain
IPR001610 PAC motif
IPR011598 Helix-loop-helix DNA-binding
IPR013655 PAS fold-3
IPR013767 PAS fold
Graphical View of Protein Domain Structure
References
(Earliest) J:47665 Hogenesch JB et al., "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors." Proc Natl Acad Sci U S A 1998 May 12;95(10):5474-9
(Latest) J:152838 Fu H et al., "A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development." J Neurosci 2009 Sep 9;29(36):11399-408
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory