Symbol
Name
ID
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Synonyms
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2310035O07Rik, A130070J02Rik, MMAC1, TEP1
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(54)
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Alleles
and
phenotypes
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All alleles(48) :
Targeted, knock-out(6)
Targeted, other(7)
Gene trapped(34)
Chemically induced(1)
| Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis. |
Associated Human Diseases (5)
Alleles Annotated to Human Diseases (6)
Phenotype Images (5)
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(369 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (26 records)
Data Summary:
Assays (7)
Results (47)
Tissues (42)
Images (10)
Theiler Stages: 10,14,15,16,17,18,19,22,23,25
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Assay Type |
Assays |
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Results |
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Western blot |
1 |
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2 |
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RT-PCR |
2 |
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4 |
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RNA in situ |
4 |
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41 |
cDNA source data(23)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(26)
cDNA(24)
Primer pair(2)
Antibodies(1)
Microarray probesets(4)
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Other database
links
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| EC |
3.1.3.67 |
| Ensembl Gene Model |
ENSMUSG00000013663 |
| DoTS |
DT.101162561, DT.101391857, DT.110880294, DT.493342, DT.91315431, DT.91597685, DT.97370271, DT.97402046 |
| DFCI |
TC1577438, TC1602136, TC1608718, TC1622089, TC1647285, TC1675135 |
| NIA Mouse Gene Index |
U019374, U021628, U342000, U370734 |
| Entrez Gene |
19211 |
| VEGA Gene Model |
OTTMUSG00000021203 |
| International Mouse Knockout Project Status |
Pten |
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Protein
domains
|
| InterPro ID |
Description |
| IPR000340 |
Dual specificity phosphatase, catalytic domain |
| IPR008973 |
C2 calcium/lipid-binding domain, CaLB |
| IPR014019 |
Phosphatase tensin type |
| IPR014020 |
Tensin phosphatase, C2 domain |
| IPR016130 |
Protein-tyrosine phosphatase, active site |
| IPR017361 |
Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:39352
Steck PA et al.,
"Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers."
Nat Genet 1997 Apr;15(4):356-62
(Latest)
J:154070
Finlay DK et al.,
"Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes."
J Exp Med 2009 Oct 26;206(11):2441-54
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All references(306)
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Other
accession IDs
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MGD-MRK-39582, MGI:1917411, MGI:2147557
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