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Fzd8 Gene Detail
 Symbol
Name
ID
Fzd8
frizzled homolog 8 (Drosophila)
MGI:108460

Nomenclature History
Synonyms Fz8, mFZ8
Genetic Map
Chromosome 18
2.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 1)

Sequence Map
Chr18:9212918-9214975 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd8 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic 14370 NCBI Gene Model | MGI Sequence Detail 2058 C57BL/6J ± Kb
transcript NM_008058 RefSeq | MGI Sequence Detail 3346 -
polypeptide Q61091 UniProt | EBI | MGI Sequence Detail 685 Not Applicable
For the selected sequences
All sequences(14)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Homozygous mutation of this gene does not appear to result in a phenotype.
Polymorphisms RFLP(1) SNPs within 2kb(7 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway...
Component integral to membrane, membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: FuncBase
Expression Literature Summary: (31 records)
Data Summary: Assays (9)    Results (322)    Tissues (191)    Images (95)
Theiler Stages: 1,2,3,4,5,16,19,20,22,23,24,25,28
  Assay Type Assays   Results
      RT-PCR 4   59
      In situ reporter (knock in) 1   83
      RNA in situ 4   180
cDNA source data(20)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(28) Genomic(1) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000036904
DoTS DT.101364531
Consensus CDS Project CCDS29048.1
UniGene 184289
PDB 1IJY
DFCI TC1608824
NIA Mouse Gene Index U018390
Entrez Gene 14370
International Mouse Knockout Project Status Fzd8
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:37068 Wang Y et al., "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." J Biol Chem 1996 Feb 23;271(8):4468-76
(Latest) J:152099 Bi Y et al., "Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells." J Cell Biochem 2009 Jun 26;108(1):295-303
All references(37)
Other
accession IDs 		MGD-MRK-37504
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory