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Dvl3 Gene Detail
 Symbol
Name
ID
Dvl3
dishevelled 3, dsh homolog (Drosophila)
MGI:108100

Nomenclature History
Genetic Map
Chromosome 16
13.7 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr16:20517137-20531589 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Dvl3 ± 2 cM)
Protein SuperFamily: segment polarity protein dishevelled homolog DVL
TreeFam: TF318198
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000003233 Ensembl Gene Model | MGI Sequence Detail 14453 C57BL/6J ± Kb
transcript NM_007889 RefSeq | MGI Sequence Detail 2953 C57BL/6
polypeptide Q61062 UniProt | EBI | MGI Sequence Detail 716 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Mice homozygous for a null allele exhibit postnatal lethality associated with respiratory distress, persistent truncus arteriosis, and double outlet right ventricle.
Polymorphisms SNPs within 2kb(51 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process intracellular signaling cascade, multicellular organismal development...
Component cytoplasm, intracellular...
Function protein binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (12 records)
Data Summary: Assays (2)    Results (63)    Tissues (55)    Images (1)
Theiler Stages: 1,2,3,4,5,23,28
  Assay Type Assays   Results
      RT-PCR 2   63
cDNA source data(4)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(12) Genomic(2) cDNA(4) Primer pair(4) Other(2) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000003233
DoTS DT.101725079, DT.110721160, DT.87048903, DT.87065777
Consensus CDS Project CCDS37287.1
DFCI TC1588186, TC1629155, TC1721712
NIA Mouse Gene Index U016917
Entrez Gene 13544
International Mouse Knockout Project Status Dvl3
Protein
domains
InterPro ID Description
IPR000591 DEP domain
IPR001158 DIX
IPR001478 PDZ/DHR/GLGF
IPR003351 Dishevelled protein
IPR008339 Dishevelled region
IPR008342 Dishevelled-3 protein, C-terminal
IPR011991 Winged helix repressor DNA-binding
IPR015506 Dishevelled related protein
Graphical View of Protein Domain Structure
References
(Earliest) J:36588 Tsang M et al., "Isolation and characterization of mouse dishevelled-3." Dev Dyn 1996 Nov;207(3):253-62
(Latest) J:152701 Suriben R et al., "Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak." Nat Genet 2009 Sep;41(9):977-85
All references(19)
Other
accession IDs 		MGD-MRK-37137
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory