Symbol
Name
ID
|
|
|
Synonyms
|
Madh2, Madr2, Smad 2
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(20)
|
Alleles
and
phenotypes
|
All alleles(35) :
Targeted, knock-out(11)
Targeted, other(7)
Gene trapped(16)
Chemically induced(1)
| Homozygous embryos die at day 6.5-8.5 with multiple defects, including failed gastrulation, lack of mesoderm, visceral endoderm dysfunction and failure to form anterior-posterior axis. Heterozygotes may show gastrulation defects and lack mandible or eyes. |
Phenotype Images (1)
|
|
Polymorphisms
|
SNPs within 2kb(308 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (75 records)
Data Summary:
Assays (12)
Results (261)
Tissues (198)
Images (56)
Theiler Stages: 2,3,4,5,7,8,9,10,11,13,14,15,17,19,20,21,22,23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
2 |
|
9 |
| |
RT-PCR |
2 |
|
21 |
| |
RNA in situ |
4 |
|
43 |
| |
Immunohistochemistry |
2 |
|
181 |
| |
Northern blot |
2 |
|
7 |
cDNA source data(10)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(18)
Genomic(3)
cDNA(12)
Primer pair(2)
Other(1)
Antibodies(4)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:34765
Baker JC et al.,
"A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway."
Genes Dev 1996 Aug 1;10(15):1880-9
(Latest)
J:156253
Tateossian H et al.,
"Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant."
Pathogenetics 2009;2(1):5
|
All references(147)
|
Other
accession IDs
|
MGD-MRK-37087
|
|
Analysis Tools
MGI BioMart
