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Bag1 Gene Detail
 Symbol
Name
ID
Bag1
BCL2-associated athanogene 1
MGI:108047


Nomenclature History
Synonyms Rap46
Genetic Map
Chromosome 4
cytoband B1
 
Mapping data( 2)
Sequence Map
Chr4:40883431-40895314 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: molecular chaperone regulator BAG-1
TreeFam: TF102011
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000006605 VEGA Gene Model | MGI Sequence Detail 11884 C57BL/6J ± Kb
transcript NM_009736 RefSeq | MGI Sequence Detail 1352 C57BL/6
polypeptide Q60739 UniProt | EBI | MGI Sequence Detail 355 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(1) Gene trapped(7)
Homozygous null mice display embryonic lethality and liver hypoplasia.
Polymorphisms SNPs within 2kb(14 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(7)
Process anti-apoptosis, apoptosis...
Component cytosol, nucleus...
Function protein binding
External Resources: MouseFunc
Expression Literature Summary: (5 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(137)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(139) Genomic(1) cDNA(137) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000028416
DoTS DT.494764, DT.91556592
UniGene 688
PDB 1I6Z
DFCI TC1574471
NIA Mouse Gene Index U024964
Entrez Gene 12017
VEGA Gene Model OTTMUSG00000006605
International Mouse Knockout Project Status Bag1
Protein
domains
InterPro ID Description
IPR000626 Ubiquitin
IPR003103 Apoptosis regulator, Bcl-2 protein, BAG
IPR017093 Molecular chaperone regulator BAG-1
IPR019955 Ubiquitin supergroup
Graphical View of Protein Domain Structure
References
(Earliest) J:34759 Takayama S et al., "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity." Cell 1995 Jan 27;80(2):279-84
(Latest) J:137204 Maeng S et al., "BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments." Proc Natl Acad Sci U S A 2008 Jun 24;105(25):8766-71
All references(17)
Other
accession IDs
MGD-MRK-37083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory