Symbol
Name
ID
|
|
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Synonyms
|
B230113H15Rik, Rho-kinase, Rock-II, Rock2m, ROKalpha
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Genetic Map
|
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Chromosome 12
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cytoband A3
|
|
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Mapping data(
3)
|
|
|
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Sequence Map
|
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Mammalian
homology
|
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Sequences
|
All sequences(38)
|
Alleles
and
phenotypes
|
All alleles(11) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(9)
| Mice homozygous for disruptions in this genes tend to die before birth those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults. |
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Polymorphisms
|
SNPs within 2kb(493 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (15 records)
Data Summary:
Assays (5)
Results (12)
Tissues (9)
Images (5)
Theiler Stages: 11,14,15,17,18,19,21,26
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
2 |
|
4 |
| |
RT-PCR |
1 |
|
3 |
| |
RNA in situ |
2 |
|
5 |
cDNA source data(184)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(185)
cDNA(184)
Primer pair(1)
Antibodies(2)
Microarray probesets(3)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000861 |
HR1-like rho-binding repeat |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR001849 |
Pleckstrin homology |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR011993 |
Pleckstrin homology-type |
| IPR015008 |
Rho Binding |
| IPR015751 |
Rho-associated coiled-coil containing protein kinase |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
| IPR017892 |
Protein kinase, C-terminal |
| IPR020684 |
Rho-associated coiled-coil containing protein kinase-like |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:35061
Nakagawa O et al.,
"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice."
FEBS Lett 1996 Aug 26;392(2):189-93
(Latest)
J:155830
Duffy P et al.,
"Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord."
J Neurosci 2009 Dec 2;29(48):15266-76
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All references(36)
|
Other
accession IDs
|
MGD-MRK-36506, MGI:1925098
|
Analysis Tools
MGI BioMart