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Myh9 Gene Detail
 Symbol
Name
ID
Myh9
myosin, heavy polypeptide 9, non-muscle
MGI:107717

Nomenclature History
Synonyms D0Jmb2, E030044M24Rik, Myhn-1, Myhn1, myosin IIA, NMHC II-A
Genetic Map
Chromosome 15
43.3 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr15:77591017-77672605 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Myh9 ± 2 cM)
Protein SuperFamily: myosin heavy chain
TreeFam: TF333601
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016428 VEGA Gene Model | MGI Sequence Detail 81589 C57BL/6J ± Kb
transcript NM_022410 RefSeq | MGI Sequence Detail 7371 C57BL/6
polypeptide Q8VDD5 UniProt | EBI | MGI Sequence Detail 1960 Not Applicable
For the selected sequences
All sequences(68)
Alleles
and
phenotypes 		All alleles(253) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(251)
Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance but no kidney or hematopoietic defects.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(1) SNPs within 2kb(364 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(40)
Process actin filament-based movement, cell adhesion...
Component cell cortex, cell-cell adherens junction...
Function actin binding, actin filament binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (14 records)
Data Summary: Assays (1)    Results (34)    Tissues (20)
Theiler Stages: 12,13,14,15,19
  Assay Type Assays   Results
      Immunohistochemistry 1   34
cDNA source data(170)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(171) Genomic(1) cDNA(170) Antibodies(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000022443
DoTS DT.101389029, DT.101712852, DT.534505, DT.91330528, DT.94193821, DT.97413493, DT.97413496, DT.99842240
UniGene 29677
DFCI TC1573750, TC1588495, TC1589172, TC1718499
NIA Mouse Gene Index U036371
Entrez Gene 17886
VEGA Gene Model OTTMUSG00000016428
International Mouse Knockout Project Status Myh9
Protein
domains
InterPro ID Description
IPR000048 IQ calmodulin-binding region
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
Graphical View of Protein Domain Structure
References
(Earliest) J:15308 Shohet RV et al., "Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin." Proc Natl Acad Sci U S A 1989 Oct;86(20):7726-30
(Latest) J:149532 Yamamoto N et al., "Myosin II regulates extension, growth and patterning in the mammalian cochlear duct." Development 2009 Jun;136(12):1977-86
All references(42)
Other
accession IDs 		MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:2146296, MGI:2443228, MGI:97257
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory