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Kcnj11 Gene Detail
 Symbol
Name
ID
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501

Nomenclature History
Synonyms Kir6.2
Genetic Map
Chromosome 7
41.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr7:53354095-53355267 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Kcnj11 ± 2 cM)
Protein SuperFamily: G protein-activated inward rectifier potassium channel
TreeFam: TF313676
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000070561 Ensembl Gene Model | MGI Sequence Detail 1173 C57BL/6J ± Kb
transcript NM_010602 RefSeq | MGI Sequence Detail 3103 C57BL/6
polypeptide Q61743 UniProt | EBI | MGI Sequence Detail 390 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(2) Chemically induced(2)
Homozygotes for a targeted null mutation exhibit impaired insulin secretion, mild glucose intolerance, reduced glucagon secretion in response to hypoglycemia, hypoxia-induced seizure susceptibility, and stress-induced arrhythmia and sudden death.
Polymorphisms SNPs within 2kb(36 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(15)
Process ion transport, potassium ion import...
Component integral to membrane, membrane...
Function ATP binding, ATP-activated inward rectifier potassium channel activity...
External Resources: MouseFunc
Expression Literature Summary: (4 records)
Data Summary: Assays (3)    Results (6)    Tissues (5)    Images (1)
Theiler Stages: 22,25,28
  Assay Type Assays   Results
      RT-PCR 2   5
      RNA in situ 1   1
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(17) Genomic(3) cDNA(13) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000070561
DoTS DT.55282641
UniGene 333863
DFCI TC1582596
NIA Mouse Gene Index U028550
Entrez Gene 16514
International Mouse Knockout Project Status Kcnj11
Protein
domains
InterPro ID Description
IPR001838 Potassium channel, inwardly rectifying, Kir-like
IPR003279 Potassium channel, inwardly rectifying, Kir6.2
IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR013521 Potassium channel, inwardly rectifying, Kir, conserved region 2
IPR014756 Immunoglobulin E-set
IPR016449 Potassium channel, inwardly rectifying, Kir
Graphical View of Protein Domain Structure
References
(Earliest) J:30315 Sakura H et al., "Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle." FEBS Lett 1995 Dec 27;377(3):338-44
(Latest) J:140800 Lybaert P et al., "KATP channel subunits are expressed in the epididymal epithelium in several mammalian species." Biol Reprod 2008 Aug;79(2):253-61
All references(74)
Other
accession IDs 		MGD-MRK-36069, MGI:2142042, MGI:2142236
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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