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Plcb2 Gene Detail
 Symbol
Name
ID
Plcb2
phospholipase C, beta 2
MGI:107465

Nomenclature History
Synonyms B230205M18Rik
Genetic Map
Chromosome 2
67.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr2:118533253-118554325 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Plcb2 ± 2 cM)
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
TreeFam: TF313216
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000015372 VEGA Gene Model | MGI Sequence Detail 21073 C57BL/6J ± Kb
transcript NM_177568 RefSeq | MGI Sequence Detail 5145 C57BL/6
polypeptide A3KGF7 UniProt | EBI | MGI Sequence Detail 1181 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Homozygous mutant mice showed an increased sensitivity to both bacterial and viral infections and exhibited abnormal taste perception in which sweet, umami, and bitter stimuli could not be sensed.
Polymorphisms RFLP(1) SNPs within 2kb(106 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process intracellular signaling cascade, lipid catabolic process...
Function calcium ion binding, hydrolase activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(2)
Pathways
phospholipases
Other database
links
EC 3.1.4.11
Ensembl Gene Model ENSMUSG00000040061
DoTS DT.91300093, DT.91388987, DT.91556036, DT.94239526, DT.97352241
Consensus CDS Project CCDS16582.1
UniGene 215156
DFCI TC1606244, TC1632486, TC1644457, TC1647627
NIA Mouse Gene Index U023216
Entrez Gene 18796
VEGA Gene Model OTTMUSG00000015372
International Mouse Knockout Project Status Plcb2
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phospholipase C, phosphoinositol-specific, C-terminal (PLC)
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR011992 EF-hand-like domain
IPR014815 PLC-beta, C-terminal
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR018029 C2 membrane targeting protein
Graphical View of Protein Domain Structure
References
(Earliest) J:30483 Hempel WM et al., "Expression of phospholipase C isozymes by murine B lymphocytes." J Immunol 1991 Jun 1;146(11):3713-20
(Latest) J:155351 Grinberg S et al., "Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype." Am J Pathol 2009 Dec;175(6):2439-53
All references(22)
Other
accession IDs 		MGD-MRK-35937, MGI:2139001, MGI:3036256
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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