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Ccr5 Gene Detail
 Symbol
Name
ID
Ccr5
chemokine (C-C motif) receptor 5
MGI:107182


Nomenclature History
Synonyms CD195, Cmkbr5
Genetic Map
Chromosome 9
72.0 cM, cytoband F
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr9:124036312-124041920 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ccr5 ± 2 cM)
Protein SuperFamily: chemokine receptor
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12774 NCBI Gene Model | MGI Sequence Detail 5609 C57BL/6J ± Kb
transcript NM_009917 RefSeq | MGI Sequence Detail 2926 C57BL/6
polypeptide P51682 UniProt | EBI | MGI Sequence Detail 354 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(3) Targeted, other(2)
Mice that are homozygous for null alleles have leukocytes with defective migration and adhesion, are more susceptibility to fungal & bacterial infections, have increased length of allograft survival, and have decreased susceptibility to endotoxin shock.
Polymorphisms RFLP(1) SNPs within 2kb(110 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process defense response, G-protein coupled receptor protein signaling pathway...
Component external side of plasma membrane, integral to membrane...
Function C-C chemokine receptor activity, G-protein coupled receptor activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (51)    Tissues (50)    Images (2)
Theiler Stages: 13,20,23,28
  Assay Type Assays   Results
      RT-PCR 1   46
      RNase protection 1   5
cDNA source data(48)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(53) Genomic(2) cDNA(48) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000079227
DoTS DT.101160273, DT.99860465
Consensus CDS Project CCDS40821.1
UniGene 14302
DFCI TC1576052
NIA Mouse Gene Index U011205
Entrez Gene 12774
International Mouse Knockout Project Status Ccr5
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR000355 Chemokine receptor
IPR002240 C-C chemokine receptor, type 5
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:32263 Boring L et al., "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9." J Biol Chem 1996 Mar 29;271(13):7551-8
(Latest) J:155835 Dehmel S et al., "Chemokine receptor Ccr5 deficiency induces alternative macrophage activation and improves long-term renal allograft outcome." Eur J Immunol 2010 Jan;40(1):267-78
All references(122)
Other
accession IDs
MGD-MRK-35643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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