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Ppp3ca Gene Detail
 Symbol
Name
ID
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
MGI:107164


Nomenclature History
Synonyms 2900074D19Rik, Caln, Calna, CN, CnA, PP2B alpha 1, PP2BA alpha
Genetic Map
Chromosome 3
Syntenic
 
Mapping data( 2)
Sequence Map
Chr3:136333088-136600691 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: serine/threonine protein phosphatase 2B catalytic subunit
TreeFam: TF105557
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016446 VEGA Gene Model | MGI Sequence Detail 267604 C57BL/6J ± Kb
transcript NM_008913 RefSeq | MGI Sequence Detail 2194 C57BL/6
polypeptide P63328 UniProt | EBI | MGI Sequence Detail 521 Not Applicable
For the selected sequences
All sequences(47)
Alleles
and
phenotypes
All alleles(12) : Targeted, knock-out(1) Gene trapped(11)
Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(1079 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process calcium ion transport, dephosphorylation...
Component calcineurin complex, cytosol...
Function calmodulin binding, hydrolase activity...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (2)    Results (7)    Tissues (5)    Images (2)
Theiler Stages: 21,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   7
cDNA source data(125)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(127) cDNA(125) Primer pair(2)
Microarray probesets(3)
Other database
links
EC 3.1.3.16
Ensembl Gene Model ENSMUSG00000028161
DoTS DT.101409017, DT.101725256, DT.101725390, DT.535071, DT.87072611, DT.94347221
Consensus CDS Project CCDS17860.1
UniGene 331389
DFCI TC1574453, TC1587797, TC1653682
NIA Mouse Gene Index U003894
Entrez Gene 19055
VEGA Gene Model OTTMUSG00000016446
International Mouse Knockout Project Status Ppp3ca
Protein
domains
InterPro ID Description
IPR004843 Metallophosphoesterase
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Graphical View of Protein Domain Structure
References
(Earliest) J:9480 Kincaid RL et al., "Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin." Proc Natl Acad Sci U S A 1988 Dec;85(23):8983-7
(Latest) J:155500 Xifro X et al., "Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity." Neurobiol Dis 2009 Dec;36(3):461-9
All references(58)
Other
accession IDs
MGD-MRK-1735, MGD-MRK-1736, MGD-MRK-35625, MGI:1920287, MGI:2139807, MGI:2139982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory