Symbol
Name
ID
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Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
MGI:106217
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Nomenclature History
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Synonyms
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alpha1E, Cav2.3, Cchra1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(25)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(3)
Targeted, other(3)
Gene trapped(1)
| Homozygotes for targeted null mutations exhibit altered R-type Ca2+ channels, increased timidity and body weight, impaired glucose tolerance, reduced locomotor activity, and lack of the cocaine stimulation of locomotor response. |
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Polymorphisms
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All PCR and RFLP(3) :
PCR(1)
RFLP(2)
SNPs within 2kb(1855 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (4 records)
Data Summary:
Assays (2)
Results (6)
Tissues (5)
Theiler Stages: 15,20,23,25,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
2 |
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6 |
cDNA source data(18)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(24)
Genomic(2)
cDNA(19)
Primer pair(3)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR002077 |
Voltage-dependent calcium channel, alpha-1 subunit |
| IPR005449 |
Voltage-dependent calcium channel, R-type, alpha-1 subunit |
| IPR005821 |
Ion transport |
| IPR014873 |
Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
| IPR018249 |
EF-HAND 2 |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:19970
Williams ME et al.,
"Structure and functional characterization of neuronal alpha 1E calcium channel subtypes."
J Biol Chem 1994 Sep 2;269(35):22347-57
(Latest)
J:151465
Hildebrand ME et al.,
"Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines."
J Neurosci 2009 Aug 5;29(31):9668-82
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All references(39)
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Other
accession IDs
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MGD-MRK-33909
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Analysis Tools
MGI BioMart
