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Shc3 Gene Detail
 Symbol
Name
ID
Shc3
src homology 2 domain-containing transforming protein C3
MGI:106179

Nomenclature History
Synonyms N-Shc, Rai, ShcC
Genetic Map
Chromosome 13
29.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr13:51526412-51662453 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Shc3 ± 2 cM)
Protein SuperFamily: SHC-transforming protein
TreeFam: TF315807
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000021448 Ensembl Gene Model | MGI Sequence Detail 136042 C57BL/6J ± Kb
transcript NM_009167 RefSeq | MGI Sequence Detail 1540 -
polypeptide Q61120 UniProt | EBI | MGI Sequence Detail 474 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes 		All alleles(3) : Targeted, other(1) Gene trapped(2)
Mice homozygous for disruptions in this gene display a normal phenotype.
Polymorphisms RFLP(1) SNPs within 2kb(480 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process intracellular signaling cascade, learning or memory...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(16)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021448
DoTS DT.110958830, DT.91332858
UniGene 131870
DFCI TC1591371
NIA Mouse Gene Index U034776
Entrez Gene 20418
International Mouse Knockout Project Status Shc3
Protein
domains
InterPro ID Description
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID/PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 Pleckstrin homology-type
Graphical View of Protein Domain Structure
References
(Earliest) J:32205 O'Bryan JP et al., "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain." Proc Natl Acad Sci U S A 1996 Apr 2;93(7):2729-34
(Latest) J:142897 Savino MT et al., "Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation." J Immunol 2009 Jan 1;182(1):301-8
All references(14)
Other
accession IDs 		MGD-MRK-33869
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory