Symbol
Name
ID
|
|
|
Synonyms
|
cholesterol 7 alpha hydroxylase
|
|
Genetic Map
|
|
Chromosome 4
|
Syntenic
|
|
|
|
Mapping data(
4)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(18)
|
Alleles
and
phenotypes
|
All alleles(1) :
Targeted, knock-out(1)
| Mice homozygous for disruption of this gene experience severe neonatal and postnatal lethality. Supplementation of the maternal diet with fat soluble vitamins and cholic acid starting before birth alleviates much of the phenotype. |
Phenotype Images (3)
|
|
Polymorphisms
|
RFLP(1)
SNPs within 2kb(99 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (2 records)
cDNA source data(15)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(20)
Genomic(4)
cDNA(15)
Other(1)
Microarray probesets(2)
|
|
Pathways
|
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:18307
Tzung KW et al.,
"Structure of the mouse cholesterol 7 alpha-hydroxylase gene."
Genomics 1994 May 1;21(1):244-7
(Latest)
J:124949
Kurosu H et al.,
"Tissue-specific Expression of betaKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21."
J Biol Chem 2007 Sep 14;282(37):26687-95
|
All references(32)
|
Other
accession IDs
|
MGD-MRK-33776
|
