Symbol
Name
ID
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Synonyms
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A230106A15Rik, Patched 1, Ptc, Ptc1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(43)
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Alleles
and
phenotypes
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All alleles(39) :
Targeted, knock-out(5)
Targeted, other(4)
Gene trapped(29)
Spontaneous(1)
| Homozygous null embryos die by day 10 with neural tube defects. Heterozygotes are large with excess cerebellar granule cell proliferation and sometimes, hindlimb defects and medulloblastomas. Hypomorphic and spontaneous mutants have reproductive defects. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
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Polymorphisms
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SNPs within 2kb(221 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (387 records)
Data Summary:
Assays (61)
Results (377)
Tissues (194)
Images (127)
Theiler Stages: 10,11,12,13,14,15,17,18,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
|
Results |
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RT-PCR |
7 |
|
30 |
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In situ reporter (knock in) |
3 |
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12 |
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RNA in situ |
47 |
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306 |
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Northern blot |
4 |
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29 |
cDNA source data(40)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(72)
Genomic(5)
cDNA(43)
Primer pair(8)
Other(16)
Microarray probesets(3)
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Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:23861
Sweet HO et al.,
"Mesenchymal dysplasia (mes)"
Mouse News Lett 1988;81():70
(Latest)
J:154102
Cain JE et al.,
"GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells."
PLoS One 2009;4(10):e7313
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All references(523)
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Other
accession IDs
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MGD-MRK-12200, MGD-MRK-33042, MGI:1924464, MGI:96966
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