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Plcb3 Gene Detail
 Symbol
Name
ID
Plcb3
phospholipase C, beta 3
MGI:104778

Nomenclature History
Genetic Map
Chromosome 19
2.5 cM, cytoband B
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr19:7028203-7044242 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Plcb3 ± 2 cM)
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
TreeFam: TF313216
Sequences
Representative Sequences Length Strain/Species Flank
genomic 18797 NCBI Gene Model | MGI Sequence Detail 16040 C57BL/6J ± Kb
transcript NM_008874 RefSeq | MGI Sequence Detail 4195 C57BL/6
polypeptide P51432 UniProt | EBI | MGI Sequence Detail 1234 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes 		All alleles(15) : Targeted, knock-out(2) Gene trapped(13)
Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids.
Polymorphisms RFLP(1) SNPs within 2kb(33 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process intracellular signaling cascade, lipid catabolic process...
Component nucleus
Function calcium ion binding, hydrolase activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (4)    Results (107)    Tissues (100)    Images (21)
Theiler Stages: 2,7,10,20,21,22,28
  Assay Type Assays   Results
      Western blot 1   8
      RT-PCR 1   2
      RNA in situ 1   93
      Immunohistochemistry 1   4
cDNA source data(60)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(65) Genomic(1) cDNA(61) Primer pair(2) Other(1) Antibodies(1)
Microarray probesets(2)
Pathways
phospholipases
Other database
links
EC 3.1.4.11
Ensembl Gene Model ENSMUSG00000024960
DoTS DT.110861242, DT.531589, DT.91559211, DT.94182212
UniGene 273204
DFCI TC1576650, TC1711989
NIA Mouse Gene Index U038667
Entrez Gene 18797
International Mouse Knockout Project Status Plcb3
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phospholipase C, phosphoinositol-specific, C-terminal (PLC)
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR009535 Protein of unknown function DUF1154
IPR011992 EF-hand-like domain
IPR014815 PLC-beta, C-terminal
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR018029 C2 membrane targeting protein
Graphical View of Protein Domain Structure
References
(Earliest) J:30483 Hempel WM et al., "Expression of phospholipase C isozymes by murine B lymphocytes." J Immunol 1991 Jun 1;146(11):3713-20
(Latest) J:151972 Xiao W et al., "Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5." Cancer Cell 2009 Aug 4;16(2):161-71
All references(30)
Other
accession IDs 		MGD-MRK-28070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory