Symbol
Name
ID
|
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Synonyms
|
CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21WAF1/CIP1, p21Cip1, p21WAF, SDI1, Waf1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(31)
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Alleles
and
phenotypes
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All alleles(13) :
Targeted, knock-out(2)
Targeted, other(2)
Gene trapped(9)
| Homozygotes for targeted null mutations exhibit increased susceptibility to a variety of tumors, elevated T cell cycling and activation, and mild autoimmunity. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (3)
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Polymorphisms
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RFLP(3)
SNPs within 2kb(287 from dbSNP Build 128)
SNPs within 2kb including multiple locations(309)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (129 records)
Data Summary:
Assays (22)
Results (115)
Tissues (42)
Images (18)
Theiler Stages: 13,14,15,17,19,20,21,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
4 |
|
15 |
| |
RT-PCR |
5 |
|
13 |
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RNA in situ |
5 |
|
14 |
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Immunohistochemistry |
1 |
|
4 |
| |
Northern blot |
7 |
|
69 |
cDNA source data(14)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(26)
Genomic(2)
cDNA(16)
Primer pair(5)
Other(3)
Antibodies(4)
Microarray probesets(3)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR003175 |
Cyclin-dependent kinase inhibitor |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:21445
el-Deiry WS et al.,
"WAF1, a potential mediator of p53 tumor suppression."
Cell 1993 Nov 19;75(4):817-25
(Latest)
J:153625
Shao C et al.,
"Mutagenesis in vivo in T cells of p21-deficient mice."
Mutat Res 2009 Nov 2;670(1-2):103-6
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All references(339)
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Other
accession IDs
|
MGD-MRK-16760, MGD-MRK-25990
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