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Gcdh Gene Detail
 Symbol
Name
ID
Gcdh
glutaryl-Coenzyme A dehydrogenase
MGI:104541

Nomenclature History
Synonyms D17825
Genetic Map
Chromosome 8
38.6 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr8:87410292-87417820 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gcdh ± 2 cM)
Protein SuperFamily: acyl-CoA dehydrogenase
TreeFam: TF105051
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000030024 VEGA Gene Model | MGI Sequence Detail 7529 C57BL/6J ± Kb
transcript NM_008097 RefSeq | MGI Sequence Detail 2197 C57BL/6
polypeptide Q60759 UniProt | EBI | MGI Sequence Detail 438 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes 		All alleles(1) : Targeted, other(1)
Homozygotes for a targeted null mutation exhibit a mild motor deficit associated with a diffuse spongiform myelinopathy and elevated levels of glutaric acid and 3-hydroxyglutaric acid.
Polymorphisms RFLP(1) SNPs within 2kb(65 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process metabolic process, oxidation reduction...
Component mitochondrial inner membrane, mitochondrion...
Function acyl-CoA dehydrogenase activity, FAD binding...
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(77)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(83) Genomic(5) cDNA(77) Primer pair(1)
Microarray probesets(2)
Other database
links
EC 1.3.99.7
Ensembl Gene Model ENSMUSG00000003809
DoTS DT.101244370, DT.101337523, DT.94358457, DT.94358465
Consensus CDS Project CCDS22482.1
UniGene 2475
DFCI TC1577178, TC1665435, TC1685451, TC1694433
NIA Mouse Gene Index U030042
Entrez Gene 270076
VEGA Gene Model OTTMUSG00000030024
International Mouse Knockout Project Status Gcdh
Protein
domains
InterPro ID Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR006090 Acyl-CoA oxidase/dehydrogenase, type 1
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR006092 Acyl-CoA dehydrogenase, N-terminal
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase
IPR013764 Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:28406 Koeller DM et al., "Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene." Genomics 1995 Aug 10;28(3):508-12
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(17)
Other
accession IDs 		MGD-MRK-25973, MGI:2142490, MGI:2142887
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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