Symbol
Name
ID
|
Nfatc3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
MGI:103296
|
Nomenclature History
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Synonyms
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D8Ertd281e, NFAT4, NFATx
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(46)
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Alleles
and
phenotypes
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All alleles(37) :
Targeted, knock-out(2)
Targeted, other(1)
Gene trapped(34)
| Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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SNPs within 2kb(156 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (4)
Results (45)
Tissues (43)
Images (4)
Theiler Stages: 17,21,24,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
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12 |
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RNA in situ |
2 |
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33 |
cDNA source data(130)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(138)
cDNA(134)
Primer pair(4)
Microarray probesets(4)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR002909 |
Cell surface receptor IPT/TIG |
| IPR008366 |
Nuclear factor of activated T cells (NFAT) |
| IPR008967 |
p53-like transcription factor, DNA-binding |
| IPR011539 |
Rel homology |
| IPR013783 |
Immunoglobulin-like fold |
| IPR014756 |
Immunoglobulin E-set |
| IPR018286 |
Nuclear factor of activated T cells (NFAT), subgroup |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:24518
Lin X et al.,
"Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras."
Mol Cell Biol 1995 May;15(5):2754-62
(Latest)
J:153636
Zeini M et al.,
"Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling."
Development 2009 Oct;136(19):3335-45
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All references(62)
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Other
accession IDs
|
MGD-MRK-24179, MGI:1098734, MGI:2142861
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Analysis Tools
MGI BioMart
