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Acly Gene Detail
 Symbol
Name
ID
Acly
ATP citrate lyase
MGI:103251

Nomenclature History
Synonyms A730098H14Rik
Genetic Map
Chromosome 11
Syntenic
 
Mapping data( 2)
Sequence Map
Chr11:100337667-100389314 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF300560
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000006279 VEGA Gene Model | MGI Sequence Detail 51648 C57BL/6J ± Kb
transcript NM_134037 RefSeq | MGI Sequence Detail 4316 C57BL/6
polypeptide Q91V92 UniProt | EBI | MGI Sequence Detail 1091 Not Applicable
For the selected sequences
All sequences(48)
Alleles
and
phenotypes 		All alleles(31) : Gene trapped(31)
Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities.
Polymorphisms SNPs within 2kb(182 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process acetyl-CoA biosynthetic process, cellular carbohydrate metabolic process...
Component cytoplasm, intracellular...
Function ATP binding, ATP citrate synthase activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (2)    Results (95)    Tissues (95)    Images (18)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 2   95
cDNA source data(576)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(581) Genomic(2) cDNA(577) Primer pair(1) Other(1)
Microarray probesets(3)
Pathways
acetyl-CoA biosynthesis (from citrate)
Other database
links
EC 2.3.3.8
Ensembl Gene Model ENSMUSG00000020917
DoTS DT.102558055, DT.536115, DT.55134562, DT.94197479, DT.97332356, DT.97338016, DT.97346544
Consensus CDS Project CCDS25425.1
UniGene 282039
DFCI TC1573874, TC1593128, TC1598719
NIA Mouse Gene Index U033427
Entrez Gene 104112
VEGA Gene Model OTTMUSG00000006279
International Mouse Knockout Project Status Acly
Protein
domains
InterPro ID Description
IPR002020 Citrate synthase-like
IPR003781 CoA-binding
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR013816 ATP-grasp fold, subdomain 2
IPR014608 ATP-citrate synthase
IPR016040 NAD(P)-binding domain
IPR016102 Succinyl-CoA synthetase-like
IPR016141 Citrate synthase-like, core
IPR016143 Citrate synthase-like, small alpha subdomain
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:48625 Elshourbagy NA et al., "Cloning and expression of a human ATP-citrate lyase cDNA." Eur J Biochem 1992 Mar 1;204(2):491-9
(Latest) J:148527 Wellen KE et al., "ATP-citrate lyase links cellular metabolism to histone acetylation." Science 2009 May 22;324(5930):1076-80
All references(17)
Other
accession IDs 		MGD-MRK-24127, MGI:2144554, MGI:2443004
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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