Symbol
Name
ID
|
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Synonyms
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IDX-1, IPF-1, Ipf1, Mody4, pdx-1, STF-1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(16)
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Alleles
and
phenotypes
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All alleles(10) :
Targeted, knock-out(3)
Targeted, other(6)
Gene trapped(1)
| Mice homozygous for a knock-out allele exhibit postnatal lethality, abnormal pancreatic and liver development, and increased plasma glucose levels. Mice heterozygous for a knock-out allele exhibit abnormal pancreatic development and abnormal glucose homeostasis. |
Associated Human Diseases (4)
Alleles Annotated to Human Diseases (3)
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(2 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (178 records)
Data Summary:
Assays (37)
Results (366)
Tissues (104)
Images (74)
Theiler Stages: 11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
|
Results |
| |
RT-PCR |
15 |
|
272 |
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RNA in situ |
5 |
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18 |
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Immunohistochemistry |
15 |
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67 |
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Northern blot |
2 |
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9 |
cDNA source data(8)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(26)
Genomic(1)
cDNA(10)
Primer pair(11)
Other(4)
Antibodies(8)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:15273
Ohlsson H et al.,
"IPF1, a homeodomain-containing transactivator of the insulin gene."
EMBO J 1993 Nov;12(11):4251-9
(Latest)
J:152922
Golson ML et al.,
"Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas."
Mech Dev 2009 Aug-Sep;126(8-9):687-99
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All references(249)
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Other
accession IDs
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MGD-MRK-11442, MGD-MRK-23684
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