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Tbx4 Gene Detail
 Symbol
Name
ID
Tbx4
T-box 4
MGI:102556


Nomenclature History
Genetic Map
Chromosome 11
49.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr11:85699924-85729597 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Tbx4 ± 2 cM)
TreeFam: TF106341
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000001043 VEGA Gene Model | MGI Sequence Detail 29674 C57BL/6J ± Kb
transcript NM_011536 RefSeq | MGI Sequence Detail 3011 C57BL/6
polypeptide P70325 UniProt | EBI | MGI Sequence Detail 552 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(1) Targeted, other(4) Gene trapped(1)
Homozygotes for targeted null mutations exhibit stunted, apoptotic allantoises lacking vascular remodeling, fail to undergo chorioallantoic fusion, lack hindlimb buds, and die by embryonic day 10.5. Heterozygotes show mildly impaired allantois growth.
Polymorphisms RFLP(1) SNPs within 2kb(143 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process angiogenesis, embryonic limb morphogenesis...
Component nucleus
Function DNA binding, protein binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (36 records)
Data Summary: Assays (11)    Results (78)    Tissues (65)    Images (12)
Theiler Stages: 2,3,4,5,14,15,17,18,19,20,21,23,28
  Assay Type Assays   Results
      RT-PCR 1   15
      RNA in situ 10   63
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(13) Primer pair(1) Other(5)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000094
DoTS DT.87034137, DT.94146753
Consensus CDS Project CCDS25196.1
UniGene 275336
DFCI TC1583558, TC1598493
NIA Mouse Gene Index U013124
Entrez Gene 21387
VEGA Gene Model OTTMUSG00000001043
International Mouse Knockout Project Status Tbx4
Protein
domains
InterPro ID Description
IPR001699 Transcription factor, T-box
IPR008967 p53-like transcription factor, DNA-binding
IPR018186 Transcription factor, T-box, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:864 Namba T et al., "Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis." Biochem Biophys Res Commun 1992 May 15;184(3):1197-203
(Latest) J:152946 Sferruzzi-Perri AN et al., "Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice." Biol Reprod 2009 Jul;81(1):207-21
All references(47)
Other
accession IDs
MGD-MRK-19405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory