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Pou5f1 Gene Detail
 Symbol
Name
ID
Pou5f1
POU domain, class 5, transcription factor 1
MGI:101893

Nomenclature History
Synonyms Oct-3, Oct-3/4, Oct-4, Oct3/4, Oct4, Otf-3, Otf-4, Otf3, Otf3-rs7, Otf3g, Otf4
Genetic Map
Chromosome 17
19.23 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr17:35643007-35647714 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pou5f1 ± 2 cM)
Protein SuperFamily: transcription factor Oct-3
TreeFam: TF316413
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000024406 Ensembl Gene Model | MGI Sequence Detail 4708 C57BL/6J ± Kb
transcript NM_013633 RefSeq | MGI Sequence Detail 1346 C57BL/6
polypeptide P20263 UniProt | EBI | MGI Sequence Detail 352 Not Applicable
For the selected sequences
All sequences(38)
Alleles
and
phenotypes 		All alleles(71) : Targeted, knock-out(1) Targeted, other(4) Gene trapped(66)
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
Polymorphisms RFLP(7) SNPs within 2kb(23 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(38)
Process cell fate commitment, ectodermal cell fate commitment...
Component cytoplasm, nucleus...
Function chromatin binding, DNA binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (195 records)
Data Summary: Assays (71)    Results (423)    Tissues (130)    Images (102)
Theiler Stages: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   1
      RT-PCR 25   202
      RNA in situ 27   120
      Immunohistochemistry 8   50
      Northern blot 8   45
      RNase protection 2   5
cDNA source data(48)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(94) Genomic(9) cDNA(52) Primer pair(19) Other(14) Antibodies(7)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024406
DoTS DT.492255, DT.91336507
UniGene 17031
PDB 1OCP
DFCI TC1579170
NIA Mouse Gene Index U017906
Entrez Gene 18999
International Mouse Knockout Project Status Pou5f1
Protein
domains
InterPro ID Description
IPR000327 POU-specific
IPR001356 Homeobox
IPR012287 Homeodomain-related
IPR013847 POU
IPR015585 POU domain-containing protein, class 5
IPR017970 Homeobox, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:10293 Okamoto K et al., "A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells." Cell 1990 Feb 9;60(3):461-72
(Latest) J:153050 Bogani D et al., "Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination." PLoS Biol 2009 Sep;7(9):e1000196
All references(262)
Other
accession IDs 		MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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