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| Nomenclature |
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Symbol:
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Tyrc-6H
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Name:
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tyrosinase;
albino 6 Harwell
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MGI ID: |
MGI:1856305 |
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Synonyms: |
c6H |
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Gene:
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Tyr
Location:
Chr7:94577327-94641899 bp, - strand
Genetic Position: Chr7,
44.0 cM
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Mutation
origin |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: |
Radiation induced |
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Mutation: |
Deletion |
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Large intergenic deletion. (J:5437) |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Tyrc-6H. Homozygotes die soon after implantation (J:5741). Complementation studies with other lethal Tyr-alleles show that Tyrc-6H probably does not affect liver enzyme production or structure of rough endoplasmic reticulum (J:5435). Homozygotes lack a specific liver polypeptide recognizable in two-dimensional gels (J:7420). The deletion includes the Mod2 locus (J:5437).
Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435).
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| References |
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Original: |
J:5219
Hunt DM et al.,
"Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse."
J Embryol Exp Morphol 1971 Aug;26(1):111-21
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All: |
11 reference(s)
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