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Mammalian Phenotype Browser
Term Detail
MP term:abnormal mammary gland epithelium morphology
MP id: MP:0009504
Definition: any structural anomaly of the mammary gland epithelium which is normally enveloped by a basement membrane, embedded into fatty connective tissue stroma, and organized as a bilayer, with an inner luminal layer of secretory epithelial cells, and an outer basal layer; each cell layer expresses specific molecular markers; luminal epithelial cells are characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin, whereas basal cells (aka myoepithelial cells) express smooth muscle contractile proteins; in functionally differentiated mammary gland, during lactation, luminal cells produce milk, whereas myoepithelial cells are contractile and serve for milk expulsion
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-aendocrine/exocrine gland phenotype
                is-aabnormal gland morphology
                        is-aabnormal exocrine gland morphology
                                is-aabnormal apocrine gland morphology
                                        is-aabnormal mammary gland morphology
                                                is-aabnormal abdominal mammary gland morphology
                                                is-aabnormal areola morphology
                                                is-aabnormal cervical mammary gland morphology
                                                is-aabnormal inguinal mammary gland morphology
                                                is-aabnormal mammary gland connective tissue morphology
                                                is-aabnormal mammary gland development +
                                                is-aabnormal mammary gland epithelium morphology [MP:0009504] (136 genotypes, 168 annotations)
                                                        is-aabnormal mammary gland cord morphology +
                                                        is-aabnormal mammary gland duct morphology +
                                                        is-aabnormal mammary gland luminal epithelium morphology
                                                        is-aabnormal mammary gland myoepithelium morphology
                                                is-aabnormal mammary gland lobule morphology +
                                                is-aabnormal mammary gland number +
                                                is-aabnormal nipple morphology +
                                                is-aabnormal thoracic mammary gland morphology
                                                is-aabsent mammary gland
                                                is-amammary gland hyperplasia
                                                is-amammary gland hypoplasia
                                                is-apale mammary gland


mammalian phenotype
        is-aintegument phenotype
                is-aabnormal skin adnexa morphology
                        is-aabnormal mammary gland morphology
                                is-aabnormal abdominal mammary gland morphology
                                is-aabnormal areola morphology
                                is-aabnormal cervical mammary gland morphology
                                is-aabnormal inguinal mammary gland morphology
                                is-aabnormal mammary gland connective tissue morphology
                                is-aabnormal mammary gland development +
                                is-aabnormal mammary gland epithelium morphology [MP:0009504] (136 genotypes, 168 annotations)
                                        is-aabnormal mammary gland cord morphology +
                                        is-aabnormal mammary gland duct morphology +
                                        is-aabnormal mammary gland luminal epithelium morphology
                                        is-aabnormal mammary gland myoepithelium morphology
                                is-aabnormal mammary gland lobule morphology +
                                is-aabnormal mammary gland number +
                                is-aabnormal nipple morphology +
                                is-aabnormal thoracic mammary gland morphology
                                is-aabsent mammary gland
                                is-amammary gland hyperplasia
                                is-amammary gland hypoplasia
                                is-apale mammary gland

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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory