| MP term: | decreased circulating tumor necrosis factor level |
| Synonym: | decreased circulating cachectin level |
| Synonym: | decreased circulating TNFA level |
| Synonym: | decreased circulating TNF level |
| Synonym: | decreased circulating tumor necrosis factor alpha level |
| Synonym: | reduced circulating cachectin level |
| Synonym: | reduced circulating TNFA level |
| Synonym: | reduced circulating TNF level |
| Synonym: | reduced circulating tumor necrosis factor alpha level |
| MP id: | MP:0008554 |
| Definition: | reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium |
| Number of paths to term: | 6 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
homeostasis/metabolism phenotypeabnormal homeostasisabnormal blood homeostasisabnormal circulating protein levelabnormal circulating cytokine levelabnormal circulating tumor necrosis factor leveldecreased circulating tumor necrosis factor level [MP:0008554] (57 genotypes, 57 annotations)increased circulating tumor necrosis factor levelhomeostasis/metabolism phenotypeabnormal homeostasisabnormal protein levelabnormal circulating protein levelabnormal circulating cytokine levelabnormal circulating tumor necrosis factor leveldecreased circulating tumor necrosis factor level [MP:0008554] (57 genotypes, 57 annotations)increased circulating tumor necrosis factor levelhomeostasis/metabolism phenotypeabnormal homeostasisabnormal protein levelabnormal intercellular signaling peptide or protein levelabnormal cytokine levelabnormal circulating cytokine levelabnormal circulating tumor necrosis factor leveldecreased circulating tumor necrosis factor level [MP:0008554] (57 genotypes, 57 annotations)increased circulating tumor necrosis factor levelhomeostasis/metabolism phenotypeabnormal homeostasisabnormal protein levelabnormal intercellular signaling peptide or protein levelabnormal cytokine levelabnormal tumor necrosis factor levelabnormal circulating tumor necrosis factor leveldecreased circulating tumor necrosis factor level [MP:0008554] (57 genotypes, 57 annotations)increased circulating tumor necrosis factor levelimmune system phenotypeabnormal immune system physiologyabnormal immune serum protein physiologyabnormal cytokine levelabnormal circulating cytokine levelabnormal circulating tumor necrosis factor leveldecreased circulating tumor necrosis factor level [MP:0008554] (57 genotypes, 57 annotations)increased circulating tumor necrosis factor levelimmune system phenotypeabnormal immune system physiologyabnormal immune serum protein physiologyabnormal cytokine levelabnormal tumor necrosis factor levelabnormal circulating tumor necrosis factor leveldecreased circulating tumor necrosis factor level [MP:0008554] (57 genotypes, 57 annotations)increased circulating tumor necrosis factor levelMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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