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Mammalian Phenotype Browser
Term Detail
MP term:decreased circulating tumor necrosis factor level
Synonym: decreased circulating cachectin level
Synonym: decreased circulating TNFA level
Synonym: decreased circulating TNF level
Synonym: decreased circulating tumor necrosis factor alpha level
Synonym: reduced circulating cachectin level
Synonym: reduced circulating TNFA level
Synonym: reduced circulating TNF level
Synonym: reduced circulating tumor necrosis factor alpha level
MP id: MP:0008554
Definition: reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahomeostasis/metabolism phenotype
                is-aabnormal homeostasis
                        is-aabnormal blood homeostasis
                                is-aabnormal circulating protein level
                                        is-aabnormal circulating cytokine level
                                                is-aabnormal circulating tumor necrosis factor level
                                                        is-adecreased circulating tumor necrosis factor level [MP:0008554] (62 genotypes, 62 annotations)
                                                        is-aincreased circulating tumor necrosis factor level


mammalian phenotype
        is-ahomeostasis/metabolism phenotype
                is-aabnormal homeostasis
                        is-aabnormal protein level
                                is-aabnormal circulating protein level
                                        is-aabnormal circulating cytokine level
                                                is-aabnormal circulating tumor necrosis factor level
                                                        is-adecreased circulating tumor necrosis factor level [MP:0008554] (62 genotypes, 62 annotations)
                                                        is-aincreased circulating tumor necrosis factor level


mammalian phenotype
        is-ahomeostasis/metabolism phenotype
                is-aabnormal homeostasis
                        is-aabnormal protein level
                                is-aabnormal intercellular signaling peptide or protein level
                                        is-aabnormal cytokine level
                                                is-aabnormal circulating cytokine level
                                                        is-aabnormal circulating tumor necrosis factor level
                                                                is-adecreased circulating tumor necrosis factor level [MP:0008554] (62 genotypes, 62 annotations)
                                                                is-aincreased circulating tumor necrosis factor level


mammalian phenotype
        is-ahomeostasis/metabolism phenotype
                is-aabnormal homeostasis
                        is-aabnormal protein level
                                is-aabnormal intercellular signaling peptide or protein level
                                        is-aabnormal cytokine level
                                                is-aabnormal tumor necrosis factor level
                                                        is-aabnormal circulating tumor necrosis factor level
                                                                is-adecreased circulating tumor necrosis factor level [MP:0008554] (62 genotypes, 62 annotations)
                                                                is-aincreased circulating tumor necrosis factor level


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune serum protein physiology
                                is-aabnormal cytokine level
                                        is-aabnormal circulating cytokine level
                                                is-aabnormal circulating tumor necrosis factor level
                                                        is-adecreased circulating tumor necrosis factor level [MP:0008554] (62 genotypes, 62 annotations)
                                                        is-aincreased circulating tumor necrosis factor level


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune serum protein physiology
                                is-aabnormal cytokine level
                                        is-aabnormal tumor necrosis factor level
                                                is-aabnormal circulating tumor necrosis factor level
                                                        is-adecreased circulating tumor necrosis factor level [MP:0008554] (62 genotypes, 62 annotations)
                                                        is-aincreased circulating tumor necrosis factor level

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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory